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B12 injection shots can usually be felt within 24 hours (and a change should show in blood tests after a month or two) A high dose of B12 oral supplementation takes the same time as an injection: roughly 24 hours to feel an improvement and then up to 2 months to show in blood markers
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More specialized markers such as methylmalonic acid or homocysteine, which can clarify borderline cases, also take weeks to shift
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For instance, one study noted that individuals who regularly took vitamin B12 supplements gained between 2.5 to 17 fewer pounds (1.2 to 7.7 kg) over a decade than those who didn't supplement
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